ORIGINAL PAPERS

   BREAST CANCER

Aromatase Inhibitors: Are There Differences Between Steroidal and Nonsteroidal Aromatase Inhibitors and Do They Matter?

William R. Miller, John Bartlett, Angela M. H. Brodie, Robert W. Brueggemeier, Enrico di Salle, Per Eystein Lønning, Antonio Llombart, Nicolai Maass, Thierry Maudelonde, Hironobu Sasano, Paul E. Goss
The Oncologist 2008; 13: 829-837; doi:10.1634/theoncologist.2008-0055
[Abstract] [Full Text] [PDF]  

SUMMARY: This review summarizes the available evidence regarding the known differences between the steroidal and nonsteroidal classes of aromatase inhibitor and evaluates their potential clinical impact.

Comparison of HER-2 and Hormone Receptor Expression in Primary Breast Cancers and Asynchronous Paired Metastases: Impact on Patient Management

Valentina Guarneri, Simona Giovannelli, Guido Ficarra, Stefania Bettelli, Antonino Maiorana, Federico Piacentini, Elena Barbieri, Maria Vittoria Dieci, Roberto D'Amico, Gordana Jovic, PierFranco Conte
The Oncologist 2008; 13: 838-844; doi:10.1634/theoncologist.2008-0048
[Abstract] [Full Text] [PDF]  

SUMMARY: This study evaluated the HER-2 and hormone receptor status of 75 breast cancer patients in samples from primary tumors and paired metastases. A change in status was found in a substantial proportion of patients, which could affect the treatment options for these patients.

Selected Combination Therapy with Sorafenib: A Review of Clinical Data and Perspectives in Advanced Solid Tumors

Lissandra Dal Lago, Véronique D'Hondt, Ahmad Awada
The Oncologist 2008; 13: 845-858; doi:10.1634/theoncologist.2007-0233
[Abstract] [Full Text] [PDF]  

SUMMARY: This review summarizes the early clinical studies of sorafenib with cytotoxic agents and discusses future perspectives of these combinations in different tumor types.

The Use of TLR7 and TLR8 Ligands for the Enhancement of Cancer Immunotherapy

Evelien L. J. M. Smits, Peter Ponsaerts, Zwi N. Berneman, Viggo F. I. Van Tendeloo
The Oncologist 2008; 13: 859-875; doi:10.1634/theoncologist.2008-0097
[Abstract] [Full Text] [PDF]  

SUMMARY: This review describes the agonists of Toll-like receptors 7 and 8 that are known so far, as well as their contribution to antitumor responses by affecting immune cells, tumor cells, and the tumor microenvironment.

Disparities in the Use of Chemotherapy and Monoclonal Antibody Therapy for Elderly Advanced Colorectal Cancer Patients in the Community Oncology Setting

Trevor McKibbin, Christopher R. Frei, Rebecca E. Greene, Peter Kwan, Jody Simon, Jim M. Koeller
The Oncologist 2008; 13: 876-885; doi:10.1634/theoncologist.2008-0061
[Abstract] [Full Text] [PDF]  

SUMMARY: This study evaluates the treatment of advanced colorectal cancer in community oncology practices, focusing on age-related differences in treatment and outcome.

Radiation Treatment Breaks and Ulcerative Mucositis in Head and Neck Cancer

Gregory Russo, Robert Haddad, Marshall Posner, Mitchell Machtay
The Oncologist 2008; 13: 886-898; doi:10.1634/theoncologist.2008-0024
[Abstract] [Full Text] [PDF]  

SUMMARY: This article reviews data on the clinical consequences of radiation treatment breaks, the association between ulcerative mucositis and radiation treatment breaks, and possible strategies to prevent radiation treatment breaks by reducing ulcerative mucositis in the management of head and neck cancer.

Multidisciplinary Management of Locally Advanced SCCHN: Optimizing Treatment Outcomes

K. Kian Ang
The Oncologist 2008; 13: 899-910; doi:10.1634/theoncologist.2007-0157
[Abstract] [Full Text] [PDF]  

SUMMARY: This article reviews the recent data that have shaped the current approach to treatment for locally advanced squamous cell carcinoma of the head and neck and addresses some of the practical challenges of implementing multimodality treatment.

Osteonecrosis of the Maxilla and Mandible in Patients with Advanced Cancer Treated with Bisphosphonate Therapy

Cherry L. Estilo, Catherine H. Van Poznak, Tijaana Wiliams, George C. Bohle, Phyu T. Lwin, Qin Zhou, Elyn R. Riedel, Diane L. Carlson, Heiko Schoder, Azeez Farooki, Monica Fornier, Jerry L. Halpern, Steven J. Tunick, Joseph M. Huryn
The Oncologist 2008; 13: 911-920; doi:10.1634/theoncologist.2008-0091
[Abstract] [Full Text] [PDF]  

SUMMARY: The manuscript presents a retrospective study of the association between patient, tumor, and dental characteristics and the development of osteonecrosis of the jaw in patients evaluated in the dental clinic at a tertiary cancer center following i.v. bisphosphonate therapy.

Commercialized Multigene Predictors of Clinical Outcome for Breast Cancer

Jeffrey S. Ross, Christos Hatzis, W. Fraser Symmans, Lajos Pusztai, Gabriel N Hortobágyi
The Oncologist 2008; 13: 921; doi:10.1634/theoncologist.2007-0248erratum
[Full Text] [PDF]  

Reflections

Charles J. Murphy
The Oncologist 2008; 13: 3016-3018; doi:10.1634/theoncologist.2008-8001
[Full Text] [PDF]  

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